Research

My goal is to understand how complex behavior arises from the interplay of an animal’s nervous system, its physical needs, and its sensory environment.

To do this, I develop novel behavioral paradigms in virtual reality that can be combined with two-photon calcium imaging to monitor and perturb neural circuits in actively navigating animals. This approach is complemented with connectomic analysis as well as behavioral studies in unrestrained animals and modeling.
I have applied these methods to study navigation in flies and crickets.


Fly Navigation VR

Current work

Currently I'm working on three different projects:

First, I’m combining a virtual reality system that I developed during my PhD (see below) with two-photon calcium imaging to investigate how flies stay oriented in dynamic and cluttered two-dimensional visual environments.

In a second navigation project I am working, in close collaboration with Dennis Goldschmidt from Carlos Ribeiro’s lab (Champalimaud) and Ann Hermundstad (Janelia), on understanding behavioral strategies and neural mechanisms underlying foraging decisions in flies.

In a third, also highly collaborative project, I’ve been analyzing the central complex connectivity using the recently published fruit fly connectome.

Fly Navigation VR

Technology development and data sharing

Throughout my PhD and postdoc I developed new experimental hardware and software. I documented and shared hardware components and additional information for software tools on our lab’s tool-related website and released code as well as raw data here.

The unity-based virtual reality software tools that I’m developing at the moment in collaboration with Janelia's Scientific Computing department are freely available on github. Further, I wrote two packages in python to aid analysis of (two-photon) imaging data (fly2p) and behavior data from the virtual reality system (unityvr).

Finally, I'm on a quest to design physiology fly holders that allow for bigger visual field of view. This is an ongoing struggle...

If you are interestested in using any of these technologies and/or in collaborating, please reach out!

Past projects

Previous experimental projects have touched on different aspects of navigation in adult and larval fruit flies as well as crickets. I have also done some modeling work in cell and structural biology.


All Learning Flies Virtual Reality Behavior Unrestrained

Scientists should thrive to build a collaborative, inclusive work environment

Increasing diversity, equity and inclusion in neuroscience requires attracting diverse scientists, and retaining these scientists in an environment where they can thrive.


As a female scientist in a male-dominated field, I experience gender-based bias firsthand, and as a scientist with a chronic illness, I’m sensitized to ableist practices in academia. I found support in a women’s mentoring group at my institute. The exchange of experiences and support through a peer group is invaluable in reinforcing a sense of belonging in a workplace where oneself is in a minority. If not already in place, I would establish a similar system in future workspaces.


Contact

e-mail: haberkernh (at) janelia.hhmi.org

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Credits

This website is based on a heavily modified Jekyll Solid theme. Some of the adjustments of the layout and design were inspired by the Spetral theme from HTML5 UP. The map on the contact page was taken from Open Steet Map under the CC BY-SA license.